Metagenomic Analysis and Novel Pathogen Discovery from Human Lower Respiratory Tract Samples and Bat Fecal Samples

Project Details

Project Lead
Canping HUANG 
Project Manager
Canping HUANG 
Institution
Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention  
Discipline
Microbiology, Immunology, and Virology (611) 
Subdiscipline
26.0619 Virology 

Abstract

In recent years, the emerging and re-emerging infectious diseases, i.e. influenza viruses, coronaviruses pose high risk for human health. Majority of the current infectious pathogens are inter-species transmissible. It is indicated that the migrating and gregarious animals (such as bar-head goose and bat) and other human-contact animals (i.e. poultry, mice) are the major natural hosts of these pathogens. The geography is one of the most important factors influencing the animal behavior and migration. we will focus on the epidemiological researches of infectious pathogens in animals and the contacted human populations. The pan-viral primers and next-generation sequencing will be used in the pathogen screening and identification. We will also use the previous identified pathogen-derived major antigens and epitopes to evaluate the human immune base-line to the new pathogens. Our study will provide new and crucial references for the surveillance and control of the current emerging inter-sepcies infectious pathogens, i.e. influenza viruses, coronaviruses.

Intellectual Merit

Our study will provide new and crucial references for the surveillance and control of the current emerging inter-sepcies infectious pathogens, i.e. influenza viruses and coronaviruses, and unveil the molecular mechanism of inter-species transmission of some important infectious agents.

Broader Impacts

Our research results will be able to reveal the mechanism of cross-species spread of some important pathogens, provide guidance for the research and development of related drugs, vaccines and antibodies, thus providing a theoretical basis and technical support for the prevention and control of major diseases.

Scale of Use

We need to use computer nodes with large RAM for a week.