Discovery, Development and Bioengineering of Antimicrobial Agents from Filamentous Fungi

Project Details

Project Lead
Jaclyn Winter 
Project Manager
Jaclyn Winter 
Institution
University of Utah, Medicinal Chemistry, College of Pharmacy, Winter lab  
Discipline
Biosciences, n.e.c. (617) 
Subdiscipline
---602 Biochemistry--- 

Abstract

Secondary metabolites are specialized small molecules produced in nature and often possess a variety of biological activities that can be used toward improving our quality of life. These molecules possess exquisite chemical diversity and are often an inspiration for the development of new pharmaceutical agents. We are interested in using a genomics approach for the discovery of new antimicrobial agents from marine-derived fungi. We will use Future System resources as our platform for the de novo assembly of marine-derived fungal genomes. Due to the volume of data, this process requires a large amount of computing power.

Intellectual Merit

This work will be used to assemble the genomes of marine-derived fungi. The resulting genomes will be mined for biosynthetic clusters and the natural product potential of the fungi will be assessed.

Broader Impacts

Biological pressures can influence the chemical diversity of secondary metabolites and marine-derived fungi often produce molecules not observed in their terrestrial counterparts. These microorganisms serve as an ideal resource for drug discovery efforts and for the characterization of novel biosynthetic enzymes.

Scale of Use

Assembly of fungal genomes will require a few VMs.